The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.

Liu, Chen-Ying; Zha, Zheng-Yu; Zhou, Xin; Zhang, Heng; Huang, Wei; Zhao, Di; Li, Tingting; Chan, Siew Wee; Lim, Chun Jye; Hong, Wanjin; Zhao, Shimin; Xiong, Yue; Lei, Qun-Ying; Guan, Kun-Liang

Liu, Chen-Ying; Zha, Zheng-Yu; Zhou, Xin; Zhang, Heng; Huang, Wei; Zhao, Di; Li, Tingting; Chan, Siew Wee; Lim, Chun Jye; Hong, Wanjin; Zhao, Shimin; Xiong, Yue; Lei, Qun-Ying; Guan, Kun-Liang.

Affiliation

Liu CY; Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine.

J Biol Chem ; 285(48): 37159-69, 2010 Nov 26.

Article in En | MEDLINE | ID: mdl-20858893

Subject(s)

Intracellular Signaling Peptides and Proteins/metabolism; SKP Cullin F-Box Protein Ligases/metabolism; Signal Transduction; Animals; Casein Kinase I/genetics; Casein Kinase I/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins/chemistry; Intracellular Signaling Peptides and Proteins/genetics; Mice; NIH 3T3 Cells; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Protein Stability; SKP Cullin F-Box Protein Ligases/genetics; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / SKP Cullin F-Box Protein Ligases / Intracellular Signaling Peptides and Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Type: Article

Fulltext

XML

PubMed Links

Search on Google