Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-fâ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cipâ/âWAF1).

Wei, Min; Wanibuchi, Hideki; Nakae, Dai; Tsuda, Hiroyuki; Takahashi, Satoru; Hirose, Masao; Totsuka, Yukari; Tatematsu, Masae; Fukushima, Shoji

Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-fâ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cipâ/âWAF1).

Wei, Min; Wanibuchi, Hideki; Nakae, Dai; Tsuda, Hiroyuki; Takahashi, Satoru; Hirose, Masao; Totsuka, Yukari; Tatematsu, Masae; Fukushima, Shoji.

Affiliation

Wei M; Department of Pathology, Osaka City University Medical School, Osaka. Japan.

Cancer Sci ; 102(1): 88-94, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20964789

Subject(s)

Carcinogens/toxicity; Cyclin-Dependent Kinase Inhibitor p21/physiology; Quinolines/toxicity; Aberrant Crypt Foci/chemically induced; Animals; Cell Cycle Proteins/physiology; DNA Adducts/metabolism; DNA-(Apurinic or Apyrimidinic Site) Lyase/physiology; Glutathione S-Transferase pi/analysis; Liver/metabolism; Male; Nuclear Proteins/physiology; Rats; Rats, Inbred F344

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Carcinogens / Cyclin-Dependent Kinase Inhibitor p21 Limits: Animals Language: En Journal: Cancer Sci Year: 2011 Type: Article

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