Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler, Martina; Gan, Lu; Mazarei, Gelareh; Graham, Rona K; Liu, Lili; Bissada, Nagat; Lu, Ge; Leavitt, Blair R; Hayden, Michael R

Metzler, Martina; Gan, Lu; Mazarei, Gelareh; Graham, Rona K; Liu, Lili; Bissada, Nagat; Lu, Ge; Leavitt, Blair R; Hayden, Michael R.

Affiliation

Metzler M; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

J Neurosci ; 30(43): 14318-29, 2010 Oct 27.

Article in En | MEDLINE | ID: mdl-20980587

Subject(s)

Excitatory Amino Acid Agonists/toxicity; N-Methylaspartate/antagonists & inhibitors; N-Methylaspartate/toxicity; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Nuclear Proteins/metabolism; Protein Phosphatase 1/physiology; Protein Phosphatase 2/physiology; Animals; Cell Death/physiology; Cells, Cultured; Cerebellum/drug effects; Cerebellum/metabolism; Corpus Striatum/drug effects; Corpus Striatum/metabolism; Dizocilpine Maleate/pharmacology; Dopamine and cAMP-Regulated Phosphoprotein 32/biosynthesis; Dopamine and cAMP-Regulated Phosphoprotein 32/genetics; Excitatory Amino Acid Antagonists/pharmacology; Female; Huntingtin Protein; Male; Mice; Mutation; Nerve Tissue Proteins/genetics; Nuclear Proteins/genetics; Phosphorylation; Protein Phosphatase 1/antagonists & inhibitors; Protein Phosphatase 2/antagonists & inhibitors; Quinolinic Acid/pharmacology; Receptors, Dopamine D1/drug effects; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Stereotaxic Techniques

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / N-Methylaspartate / Excitatory Amino Acid Agonists / Protein Phosphatase 1 / Protein Phosphatase 2 / Nerve Tissue Proteins / Neurons Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Neurosci Year: 2010 Type: Article Affiliation country: Canada

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