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The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
Lunniss, Gillian E; Barnes, Ashley A; Barton, Nick; Biagetti, Matteo; Bianchi, Federica; Blowers, Stephen M; Caberlotto, Laura L; Emmons, Amanda; Holmes, Ian P; Montanari, Dino; Norris, Roz; Puckey, Gemma V; Walters, Dewi J; Watson, Steve P; Willis, John.
Affiliation
  • Lunniss GE; GlaxoSmithKline, Neurosciences Centre of Excellence for Drug Discovery, New Frontiers Science Park, Harlow, UK. gill@lunniss.net
Bioorg Med Chem Lett ; 20(24): 7341-4, 2010 Dec 15.
Article in En | MEDLINE | ID: mdl-21074426
ABSTRACT
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Spiro Compounds / Receptors, Neuropeptide Y Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Spiro Compounds / Receptors, Neuropeptide Y Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United kingdom