The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.

Shih, Tsung-Ming; Guarisco, John A; Myers, Todd M; Kan, Robert K; McDonough, John H

Shih, Tsung-Ming; Guarisco, John A; Myers, Todd M; Kan, Robert K; McDonough, John H.

Affiliation

Shih TM; Research and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA.

Toxicol Mech Methods ; 21(1): 53-62, 2011 Jan.

Article in En | MEDLINE | ID: mdl-21117832

Subject(s)

Cholinesterase Reactivators/pharmacology; Organophosphorus Compounds/toxicity; Organothiophosphorus Compounds/toxicity; Pralidoxime Compounds/pharmacology; Sarin/toxicity; Animals; Guinea Pigs; Male; Prodrugs; Seizures/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Organothiophosphorus Compounds / Pralidoxime Compounds / Sarin / Cholinesterase Reactivators Limits: Animals Language: En Journal: Toxicol Mech Methods Journal subject: TOXICOLOGIA Year: 2011 Type: Article Affiliation country: United States

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