Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.

Kent, Oliver A; Chivukula, Raghu R; Mullendore, Michael; Wentzel, Erik A; Feldmann, Georg; Lee, Kwang H; Liu, Shu; Leach, Steven D; Maitra, Anirban; Mendell, Joshua T

Kent, Oliver A; Chivukula, Raghu R; Mullendore, Michael; Wentzel, Erik A; Feldmann, Georg; Lee, Kwang H; Liu, Shu; Leach, Steven D; Maitra, Anirban; Mendell, Joshua T.

Affiliation

Kent OA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Genes Dev ; 24(24): 2754-9, 2010 Dec 15.

Article in En | MEDLINE | ID: mdl-21159816

Subject(s)

Down-Regulation/genetics; MicroRNAs/genetics; Pancreatic Neoplasms/etiology; ras Proteins/physiology; Animals; Cell Line; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Humans; Mice; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/physiology; Transcription Factors/genetics; Transcription Factors/physiology; Zebrafish; Zebrafish Proteins/genetics; ras Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Down-Regulation / Ras Proteins / MicroRNAs Limits: Animals / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2010 Type: Article Affiliation country: United States

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