Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.

Beurel, Eléonore; Yeh, Wen-I; Michalek, Suzanne M; Harrington, Laurie E; Jope, Richard S

Beurel, Eléonore; Yeh, Wen-I; Michalek, Suzanne M; Harrington, Laurie E; Jope, Richard S.

Affiliation

Beurel E; Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

J Immunol ; 186(3): 1391-8, 2011 Feb 01.

Article in En | MEDLINE | ID: mdl-21191064

Subject(s)

Cell Differentiation/immunology; Glycogen Synthase Kinase 3/physiology; Interleukin-17/biosynthesis; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/metabolism; Animals; Bone Marrow Cells/enzymology; Bone Marrow Cells/immunology; Bone Marrow Cells/metabolism; Cell Differentiation/genetics; Cell Polarity/immunology; Cells, Cultured; Dendritic Cells/enzymology; Dendritic Cells/immunology; Dendritic Cells/metabolism; Encephalomyelitis, Autoimmune, Experimental/enzymology; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/pathology; Female; Francisella tularensis/immunology; Gene Knock-In Techniques; Glycogen Synthase Kinase 3/antagonists & inhibitors; Growth Inhibitors/antagonists & inhibitors; Growth Inhibitors/physiology; Interleukin-6/antagonists & inhibitors; Interleukin-6/biosynthesis; Interleukin-6/physiology; Intestinal Mucosa/enzymology; Intestinal Mucosa/immunology; Intestinal Mucosa/pathology; Lung/enzymology; Lung/microbiology; Lung/pathology; Mice; Mice, Inbred C57BL; T-Lymphocytes, Helper-Inducer/enzymology; Tularemia/enzymology; Tularemia/immunology; Tularemia/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / T-Lymphocytes, Helper-Inducer / Interleukin-17 / Glycogen Synthase Kinase 3 Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: United States

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