Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency.

Tanaka, Hiroki; Tamura, Akitoshi; Sekai, Miho; Hamazaki, Yoko; Minato, Nagahiro

Tanaka, Hiroki; Tamura, Akitoshi; Sekai, Miho; Hamazaki, Yoko; Minato, Nagahiro.

Affiliation

Tanaka H; Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Cancer Sci ; 102(4): 784-91, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21205094

Subject(s)

DNA Damage; GTPase-Activating Proteins/physiology; Hematopoietic Stem Cells/physiology; Myeloproliferative Disorders/etiology; Nuclear Proteins/physiology; Proto-Oncogene Proteins c-myc/metabolism; Animals; Blast Crisis/etiology; Blast Crisis/metabolism; Blast Crisis/pathology; Blotting, Western; Flow Cytometry; Gamma Rays; Hematopoiesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation/genetics; Myeloproliferative Disorders/metabolism; Myeloproliferative Disorders/pathology; Proto-Oncogene Proteins c-myc/genetics; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Survival Rate; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Whole-Body Irradiation; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism; rap1 GTP-Binding Proteins/genetics; rap1 GTP-Binding Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Hematopoietic Stem Cells / Nuclear Proteins / Proto-Oncogene Proteins c-myc / GTPase-Activating Proteins / Myeloproliferative Disorders Type of study: Etiology_studies Limits: Animals Language: En Journal: Cancer Sci Year: 2011 Type: Article Affiliation country: Japan

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