Validation of isoleucine utilization targets in Plasmodium falciparum.

Istvan, Eva S; Dharia, Neekesh V; Bopp, Selina E; Gluzman, Ilya; Winzeler, Elizabeth A; Goldberg, Daniel E

Istvan, Eva S; Dharia, Neekesh V; Bopp, Selina E; Gluzman, Ilya; Winzeler, Elizabeth A; Goldberg, Daniel E.

Affiliation

Istvan ES; Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

Proc Natl Acad Sci U S A ; 108(4): 1627-32, 2011 Jan 25.

Article in En | MEDLINE | ID: mdl-21205898

Subject(s)

Isoleucine-tRNA Ligase/metabolism; Isoleucine/metabolism; Plasmodium falciparum/metabolism; Protozoan Proteins/metabolism; Adult; Animals; Anti-Bacterial Agents/pharmacology; Dose-Response Relationship, Drug; Drug Resistance/genetics; Erythrocytes/parasitology; Genome, Protozoan/genetics; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Hemoglobins/metabolism; Humans; Isoleucine/analogs & derivatives; Isoleucine/pharmacology; Isoleucine-tRNA Ligase/genetics; Microscopy, Fluorescence; Mupirocin/pharmacology; Mutation; Plasmodium falciparum/drug effects; Plasmodium falciparum/genetics; Polymorphism, Single Nucleotide; Protozoan Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Isoleucine / Isoleucine-tRNA Ligase Limits: Adult / Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2011 Type: Article Affiliation country: United States

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