Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Itoh, Norio; Tsunoda, Shin-ichi; Tsutsumi, Yasuo

Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Itoh, Norio; Tsunoda, Shin-ichi; Tsutsumi, Yasuo.

Affiliation

Nabeshi H; Osaka University, Japan.

Part Fibre Toxicol ; 8: 1, 2011 Jan 15.

Article in En | MEDLINE | ID: mdl-21235812

Subject(s)

DNA Damage; DNA/drug effects; Endocytosis/drug effects; Keratinocytes/drug effects; Nanoparticles/toxicity; Silicon Dioxide/toxicity; Cell Line; Comet Assay; Drug Therapy, Combination; Endocytosis/physiology; Humans; Nucleic Acid Synthesis Inhibitors/pharmacology; Particle Size; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / DNA / Keratinocytes / Silicon Dioxide / Endocytosis / Nanoparticles Limits: Humans Language: En Journal: Part Fibre Toxicol Journal subject: TOXICOLOGIA Year: 2011 Type: Article Affiliation country: Japan

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