Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.

Kuglstatter, Andreas; Wong, April; Tsing, Stan; Lee, Simon W; Lou, Yan; Villaseñor, Armando G; Bradshaw, J Michael; Shaw, David; Barnett, Jim W; Browner, Michelle F

Kuglstatter, Andreas; Wong, April; Tsing, Stan; Lee, Simon W; Lou, Yan; Villaseñor, Armando G; Bradshaw, J Michael; Shaw, David; Barnett, Jim W; Browner, Michelle F.

Affiliation

Kuglstatter A; Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, California 94304, USA. andreas.kuglstatter@roche.com

Protein Sci ; 20(2): 428-36, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21280133

Subject(s)

Protein Kinase Inhibitors/chemistry; Protein-Tyrosine Kinases/chemistry; Agammaglobulinaemia Tyrosine Kinase; Animals; Mice; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oxazines/chemistry; Oxazines/metabolism; Protein Kinase Inhibitors/metabolism; Protein Structure, Tertiary; Protein-Tyrosine Kinases/antagonists & inhibitors; Protein-Tyrosine Kinases/metabolism; Pyridines/chemistry; Pyridines/metabolism; X-Ray Diffraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Protein Kinase Inhibitors Limits: Animals Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2011 Type: Article Affiliation country: United States

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