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The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
Procopiou, Panayiotis A; Browning, Christopher; Buckley, Jennifer M; Clark, Kenneth L; Fechner, Lise; Gore, Paul M; Hancock, Ashley P; Hodgson, Simon T; Holmes, Duncan S; Kranz, Michael; Looker, Brian E; Morriss, Karen M L; Parton, Daniel L; Russell, Linda J; Slack, Robert J; Sollis, Steven L; Vile, Sadie; Watts, Clarissa J.
Affiliation
  • Procopiou PA; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom. pan.a.procopiou@gsk.com
J Med Chem ; 54(7): 2183-95, 2011 Apr 14.
Article in En | MEDLINE | ID: mdl-21381763
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Receptors, Histamine H1 / Rhinitis / Receptors, Histamine H3 / Drug Discovery Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Receptors, Histamine H1 / Rhinitis / Receptors, Histamine H3 / Drug Discovery Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United kingdom