Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rß2 or IL-18R&#945;.

Choi, I-K; Lee, J-S; Zhang, S-N; Park, J; Sonn, C H; Lee, K-M; Yun, C-O

Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rß2 or IL-18Rα.

Choi, I-K; Lee, J-S; Zhang, S-N; Park, J; Sonn, C H; Lee, K-M; Yun, C-O.

Affiliation

Choi IK; Graduate Program for Nanomedical Science, Yonsei University, Seoul, South Korea.

Gene Ther ; 18(9): 898-909, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21451575

Subject(s)

Genetic Therapy/methods; Interleukin-12/genetics; Interleukin-18/genetics; Melanoma, Experimental/immunology; Melanoma, Experimental/therapy; Oncolytic Virotherapy/methods; Receptors, Interleukin-12/metabolism; Receptors, Interleukin-18/metabolism; T-Lymphocytes/immunology; Adenoviridae/genetics; Animals; Cell Differentiation; Cell Line, Tumor; Interleukin-12/metabolism; Interleukin-18/metabolism; Male; Mice; Mice, Inbred C57BL; Oncolytic Viruses

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / T-Lymphocytes / Genetic Therapy / Interleukin-12 / Interleukin-18 / Oncolytic Virotherapy / Receptors, Interleukin-12 / Receptors, Interleukin-18 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2011 Type: Article Affiliation country: South Korea

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