Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.

Lansdon, Eric B; Liu, Qi; Leavitt, Stephanie A; Balakrishnan, Mini; Perry, Jason K; Lancaster-Moyer, Candra; Kutty, Nilima; Liu, Xiaohong; Squires, Neil H; Watkins, William J; Kirschberg, Thorsten A

Lansdon, Eric B; Liu, Qi; Leavitt, Stephanie A; Balakrishnan, Mini; Perry, Jason K; Lancaster-Moyer, Candra; Kutty, Nilima; Liu, Xiaohong; Squires, Neil H; Watkins, William J; Kirschberg, Thorsten A.

Affiliation

Lansdon EB; Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, USA. eric.lansdon@gilead.com

Antimicrob Agents Chemother ; 55(6): 2905-15, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21464257

Subject(s)

Anti-HIV Agents/pharmacology; HIV-1/drug effects; Pyrimidines/pharmacology; Quinazolinones/pharmacology; Ribonuclease H/antagonists & inhibitors; Amino Acid Sequence; Crystallization; HIV Reverse Transcriptase/antagonists & inhibitors; HIV Reverse Transcriptase/chemistry; HIV-1/enzymology; Molecular Conformation; Molecular Sequence Data; Pyrimidines/chemistry; Quinazolinones/chemistry; Ribonuclease H/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / HIV-1 / Ribonuclease H / Anti-HIV Agents / Quinazolinones Language: En Journal: Antimicrob Agents Chemother Year: 2011 Type: Article Affiliation country: United States

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