Invariant natural killer T-cell-deficient mice display increased CCl4 -induced hepatitis associated with CXCL1 over-expression and neutrophil infiltration.

Lisbonne, Mariette; L'Helgoualc'h, Annie; Nauwelaers, Gwendoline; Turlin, Bruno; Lucas, Catherine; Herbelin, André; Piquet-Pellorce, Claire; Samson, Michel

Lisbonne, Mariette; L'Helgoualc'h, Annie; Nauwelaers, Gwendoline; Turlin, Bruno; Lucas, Catherine; Herbelin, André; Piquet-Pellorce, Claire; Samson, Michel.

Affiliation

Lisbonne M; EA 4427 SeRAIC-IRSET, Université de Rennes, IFR 140, Rennes, France.

Eur J Immunol ; 41(6): 1720-32, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21469102

Subject(s)

Chemokine CXCL1/metabolism; Hepatitis, Animal/immunology; Liver/metabolism; Natural Killer T-Cells/metabolism; Neutrophils/metabolism; Acute Disease; Alanine/blood; Animals; Apoptosis/drug effects; Aspartate Aminotransferases/blood; Carbon Tetrachloride/administration & dosage; Carbon Tetrachloride/toxicity; Cell Movement/drug effects; Cells, Cultured; Chemokine CXCL1/genetics; Chemokine CXCL1/immunology; Hepatitis, Animal/blood; Hepatitis, Animal/chemically induced; Hepatocytes/pathology; Liver/drug effects; Liver/immunology; Liver/pathology; Matrix Metalloproteinase 8/genetics; Matrix Metalloproteinase 8/immunology; Matrix Metalloproteinase 8/metabolism; Mice; Mice, Knockout; Natural Killer T-Cells/immunology; Natural Killer T-Cells/pathology; Neutrophils/drug effects; Neutrophils/immunology; Neutrophils/pathology; Receptors, Antigen, T-Cell, alpha-beta/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemokine CXCL1 / Natural Killer T-Cells / Hepatitis, Animal / Liver / Neutrophils Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Eur J Immunol Year: 2011 Type: Article Affiliation country: France

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