Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2.

Niitsu, Yukihiro; Hakamata, Masatoshi; Goto, Yuko; Higashi, Toshinori; Shoji, Mitsuru; Sugai, Takeshi; Umezawa, Kazuo

Niitsu, Yukihiro; Hakamata, Masatoshi; Goto, Yuko; Higashi, Toshinori; Shoji, Mitsuru; Sugai, Takeshi; Umezawa, Kazuo.

Affiliation

Niitsu Y; Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.

Org Biomol Chem ; 9(12): 4635-41, 2011 Jun 21.

Article in En | MEDLINE | ID: mdl-21541373

Subject(s)

Antineoplastic Agents/metabolism; Benzamides/metabolism; Cyclohexanones/metabolism; Lipase/metabolism; NF-E2-Related Factor 2/agonists; NF-kappa B/antagonists & inhibitors; Neuroblastoma/drug therapy; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antioxidants/metabolism; Benzamides/chemical synthesis; Benzamides/pharmacology; Biocatalysis; Burkholderia cepacia/chemistry; Burkholderia cepacia/enzymology; Cell Line, Tumor; Cyclohexanones/chemical synthesis; Cyclohexanones/pharmacology; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Luciferases/analysis; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Neuroblastoma/metabolism; Reactive Oxygen Species/antagonists & inhibitors; Reactive Oxygen Species/metabolism; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / NF-kappa B / Cyclohexanones / NF-E2-Related Factor 2 / Lipase / Neuroblastoma / Antineoplastic Agents Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: Japan

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