The pharmacogenetics of NAT2 enzyme maturation in perinatally HIV exposed infants receiving isoniazid.

Zhu, Rui; Kiser, Jennifer J; Seifart, Heiner I; Werely, Cedric J; Mitchell, Charles D; D'Argenio, David Z; Fletcher, Courtney V

Zhu, Rui; Kiser, Jennifer J; Seifart, Heiner I; Werely, Cedric J; Mitchell, Charles D; D'Argenio, David Z; Fletcher, Courtney V.

Affiliation

Zhu R; Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA 90089, USA.

J Clin Pharmacol ; 52(4): 511-9, 2012 Apr.

Article in En | MEDLINE | ID: mdl-21558457

Subject(s)

Antitubercular Agents/pharmacokinetics; Arylamine N-Acetyltransferase/genetics; Isoniazid/pharmacokinetics; Isoniazid/therapeutic use; Administration, Oral; Age Factors; Antitubercular Agents/administration & dosage; Antitubercular Agents/therapeutic use; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Genotype; HIV Infections/transmission; Humans; Infant; Infectious Disease Transmission, Vertical; Isoniazid/administration & dosage; Latent Tuberculosis/prevention & control; Male; Pharmacogenetics; Pregnancy; Pregnancy Complications, Infectious/epidemiology; Prospective Studies; South Africa; Tuberculosis/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arylamine N-Acetyltransferase / Isoniazid / Antitubercular Agents Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Infant / Male / Pregnancy Country/Region as subject: Africa Language: En Journal: J Clin Pharmacol Year: 2012 Type: Article Affiliation country: United States

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