The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.

Ryskamp, Daniel A; Witkovsky, Paul; Barabas, Peter; Huang, Wei; Koehler, Christopher; Akimov, Nikolay P; Lee, Suk Hee; Chauhan, Shiwani; Xing, Wei; Rentería, René C; Liedtke, Wolfgang; Krizaj, David

Ryskamp, Daniel A; Witkovsky, Paul; Barabas, Peter; Huang, Wei; Koehler, Christopher; Akimov, Nikolay P; Lee, Suk Hee; Chauhan, Shiwani; Xing, Wei; Rentería, René C; Liedtke, Wolfgang; Krizaj, David.

Affiliation

Ryskamp DA; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, Interdepartmental Program in Neuroscience, and Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

J Neurosci ; 31(19): 7089-101, 2011 May 11.

Article in En | MEDLINE | ID: mdl-21562271

Subject(s)

Apoptosis/physiology; Calcium/metabolism; Retinal Ganglion Cells/physiology; TRPV Cation Channels/metabolism; Animals; Apoptosis/drug effects; Axons/metabolism; Capsaicin/pharmacology; Dendrites/metabolism; Dose-Response Relationship, Drug; Electrophysiology; Immunohistochemistry; Leucine/analogs & derivatives; Leucine/pharmacology; Mechanotransduction, Cellular/physiology; Mice; RNA, Messenger/genetics; RNA, Messenger/metabolism; Retinal Ganglion Cells/drug effects; Sulfonamides/pharmacology; TRPV Cation Channels/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Ganglion Cells / Calcium / Apoptosis / TRPV Cation Channels Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Neurosci Year: 2011 Type: Article Affiliation country: United States

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