Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1&#945; mediated by the PTEN/PI3K/Akt pathway.

Park, J H; Lee, J Y; Shin, D H; Jang, K S; Kim, H J; Kong, Gu

Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.

Park, J H; Lee, J Y; Shin, D H; Jang, K S; Kim, H J; Kong, Gu.

Affiliation

Park JH; Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Oncogene ; 30(45): 4578-89, 2011 Nov 10.

Article in En | MEDLINE | ID: mdl-21602890

Subject(s)

Breast Neoplasms/blood supply; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Neovascularization, Pathologic/genetics; PTEN Phosphohydrolase/metabolism; Phosphatidylinositol 3-Kinase/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Repressor Proteins/genetics; Animals; Breast Neoplasms/pathology; Cell Line, Tumor; Female; Forkhead Box Protein O3; Forkhead Transcription Factors/metabolism; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Mice; Mice, Inbred NOD; Polycomb Repressive Complex 1; Repressor Proteins/metabolism; Signal Transduction; Transcription, Genetic; Vascular Endothelial Growth Factor A/biosynthesis; Vascular Endothelial Growth Factor A/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Breast Neoplasms / PTEN Phosphohydrolase / Proto-Oncogene Proteins c-akt / Hypoxia-Inducible Factor 1, alpha Subunit / Phosphatidylinositol 3-Kinase / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2011 Type: Article

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