Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro.

Correale, P; Botta, C; Cusi, M G; Del Vecchio, M T; De Santi, M M; Gori Savellini, G; Bestoso, E; Apollinari, S; Mannucci, S; Marra, M; Abbruzzese, A; Aquino, A; Turriziani, M; Bonmassar, L; Caraglia, M; Tagliaferri, P

Correale, P; Botta, C; Cusi, M G; Del Vecchio, M T; De Santi, M M; Gori Savellini, G; Bestoso, E; Apollinari, S; Mannucci, S; Marra, M; Abbruzzese, A; Aquino, A; Turriziani, M; Bonmassar, L; Caraglia, M; Tagliaferri, P.

Affiliation

Correale P; Medical Oncology Unit, Department of Oncology, Siena University Hospital, Istituto Toscano Tumori, Siena, Italy. correalep@yahoo.it

Int J Cancer ; 130(7): 1577-89, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-21618510

Subject(s)

Antibodies, Monoclonal/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Colonic Neoplasms/drug therapy; Colonic Neoplasms/immunology; Dendritic Cells/drug effects; Phagocytosis/drug effects; T-Lymphocytes, Cytotoxic/drug effects; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal, Humanized; Antigen-Presenting Cells/drug effects; Antigen-Presenting Cells/immunology; Antigens, Neoplasm/immunology; Antineoplastic Combined Chemotherapy Protocols/immunology; Cell Line, Tumor; Cetuximab; Cross-Priming/drug effects; Cross-Priming/immunology; Dendritic Cells/immunology; HT29 Cells; Humans; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/immunology; Phagocytosis/immunology; T-Lymphocytes, Cytotoxic/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Dendritic Cells / T-Lymphocytes, Cytotoxic / Antineoplastic Combined Chemotherapy Protocols / Colonic Neoplasms / Antibodies, Monoclonal Limits: Humans Language: En Journal: Int J Cancer Year: 2012 Type: Article Affiliation country: Italy

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