Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.

Xia, Wenle; Liu, Zuguo; Zong, Rongrong; Liu, Leihua; Zhao, Sumin; Bacus, Sarah S; Mao, Yubin; He, Jia; Wulfkuhle, Julia D; Petricoin, Emanuel F; Osada, Takuya; Yang, Xiao-Yi; Hartman, Zachary C; Clay, Timothy M; Blackwell, Kimberly L; Lyerly, Herbert K; Spector, Neil L

Xia, Wenle; Liu, Zuguo; Zong, Rongrong; Liu, Leihua; Zhao, Sumin; Bacus, Sarah S; Mao, Yubin; He, Jia; Wulfkuhle, Julia D; Petricoin, Emanuel F; Osada, Takuya; Yang, Xiao-Yi; Hartman, Zachary C; Clay, Timothy M; Blackwell, Kimberly L; Lyerly, Herbert K; Spector, Neil L.

Affiliation

Xia W; Duke Comprehensive Cancer Research Center, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. Wenle.Xia@duke.edu

Mol Cancer Ther ; 10(8): 1367-74, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21673090

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Protein Kinase Inhibitors/pharmacology; Receptor, ErbB-2/antagonists & inhibitors; Receptor, ErbB-2/genetics; Animals; Apoptosis/genetics; Cell Line, Tumor; Cell Nucleus/metabolism; Drug Resistance, Neoplasm/genetics; Female; GTPase-Activating Proteins/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Humans; Lapatinib; Mice; Mice, Inbred NOD; Mice, SCID; Models, Biological; Phosphorylation/drug effects; Proteasome Endopeptidase Complex/metabolism; Proteasome Inhibitors; Quinazolines/pharmacology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptor, ErbB-2 / Protein Kinase Inhibitors / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2011 Type: Article Affiliation country: United States

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