Bile Duct Neoplasms/parasitology; Cholangiocarcinoma/parasitology; Histone Deacetylases/metabolism; Opisthorchiasis/genetics; Repressor Proteins/metabolism; Animals; Antigens, Helminth/analysis; Bile Duct Neoplasms/genetics; Bile Duct Neoplasms/pathology; Bile Ducts, Intrahepatic; Biomarkers/analysis; Cholangiocarcinoma/genetics; Cholangiocarcinoma/pathology; Cytokines/metabolism; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fasciola hepatica/genetics; Fasciola hepatica/metabolism; Histone Deacetylases/genetics; Host-Parasite Interactions/genetics; Humans; Immunohistochemistry; Liver Neoplasms, Experimental; Mice; Opisthorchiasis/physiopathology; Opisthorchis/genetics; Opisthorchis/immunology; Random Allocation; Real-Time Polymerase Chain Reaction; Repressor Proteins/genetics; Risk Assessment; Sensitivity and Specificity; Trans-Activators; Up-Regulation