Synthesis of cyclopentenols and cyclopentenones via nickel-catalyzed reductive cycloaddition.
J Am Chem Soc
; 133(36): 14460-6, 2011 Sep 14.
Article
in En
| MEDLINE
| ID: mdl-21819132
ABSTRACT
Strategies for the reductive cycloaddition of enals or enoates with alkynes have been developed. The enal-alkyne cycloaddition directly affords cyclopentenols, whereas the enoate-alkyne cycloaddition affords the analogous cyclopentenones. The mechanism of these processes likely involves formation and protonation of a metallacyclic intermediate. The general strategy provides a straightforward entry to five-membered ring products from simple, stable π-systems.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Am Chem Soc
Year:
2011
Type:
Article
Affiliation country:
United States