Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

Revenko, Alexey S; Gao, Dacao; Crosby, Jeff R; Bhattacharjee, Gourab; Zhao, Chenguang; May, Chris; Gailani, David; Monia, Brett P; MacLeod, A Robert

Revenko, Alexey S; Gao, Dacao; Crosby, Jeff R; Bhattacharjee, Gourab; Zhao, Chenguang; May, Chris; Gailani, David; Monia, Brett P; MacLeod, A Robert.

Affiliation

Revenko AS; Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc, Carlsbad, CA, USA.

Blood ; 118(19): 5302-11, 2011 Nov 10.

Article in En | MEDLINE | ID: mdl-21821705

Subject(s)

Factor XII Deficiency/blood; Hemorrhage/blood; Hemorrhage/etiology; Prekallikrein/deficiency; Thrombosis/blood; Thrombosis/prevention & control; Animals; Disease Models, Animal; Factor XII/antagonists & inhibitors; Factor XII/genetics; Factor XII Deficiency/genetics; Gene Knockdown Techniques; Hemorrhage/genetics; Hemostasis/genetics; Hemostasis/physiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense/administration & dosage; Oligonucleotides, Antisense/genetics; Prekallikrein/antagonists & inhibitors; Prekallikrein/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Risk Factors; Thrombosis/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Prekallikrein / Factor XII Deficiency / Hemorrhage Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

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