ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1.

Day, Bryan W; Stringer, Brett W; Spanevello, Mark D; Charmsaz, Sara; Jamieson, Paul R; Ensbey, Kathleen S; Carter, Jacinta C; Cox, Joanne M; Ellis, Vicky J; Brown, Christopher L; Walker, David G; Inglis, Po L; Allan, Suzanne; Reynolds, Brent A; Lickliter, Jason D; Boyd, Andrew W

Day, Bryan W; Stringer, Brett W; Spanevello, Mark D; Charmsaz, Sara; Jamieson, Paul R; Ensbey, Kathleen S; Carter, Jacinta C; Cox, Joanne M; Ellis, Vicky J; Brown, Christopher L; Walker, David G; Inglis, Po L; Allan, Suzanne; Reynolds, Brent A; Lickliter, Jason D; Boyd, Andrew W.

Affiliation

Day BW; Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Queensland, 4029, Brisbane, Australia. bryan.day@qimr.edu.au

Neuro Oncol ; 13(11): 1202-12, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21846680

Subject(s)

Apoptosis; Gene Expression Regulation, Neoplastic; Glioblastoma/pathology; Glioblastoma/prevention & control; Proto-Oncogene Proteins c-bcl-2/metabolism; ets-Domain Protein Elk-4/metabolism; Adult; Animals; Base Sequence; Blotting, Western; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Brain Neoplasms/prevention & control; Cell Line, Tumor; Chromatin Immunoprecipitation; Down-Regulation; Electrophoretic Mobility Shift Assay; Glioblastoma/metabolism; Humans; Luciferases/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Sequence Data; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Grading; Polymorphism, Single Nucleotide/genetics; Promoter Regions, Genetic/genetics; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/genetics; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Transfection; bcl-X Protein/genetics; bcl-X Protein/metabolism; ets-Domain Protein Elk-4/antagonists & inhibitors; ets-Domain Protein Elk-4/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Apoptosis / Glioblastoma / Proto-Oncogene Proteins c-bcl-2 / Ets-Domain Protein Elk-4 Type of study: Prognostic_studies Language: En Journal: Neuro Oncol Journal subject: NEOPLASIAS / NEUROLOGIA Year: 2011 Type: Article Affiliation country: Australia

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