The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells.

Morande, Pablo E; Zanetti, Samanta R; Borge, Mercedes; Nannini, Paula; Jancic, Carolina; Bezares, Raimundo F; Bitsmans, Alicia; González, Miguel; Rodríguez, Andrea L; Galmarini, Carlos M; Gamberale, Romina; Giordano, Mirta

Morande, Pablo E; Zanetti, Samanta R; Borge, Mercedes; Nannini, Paula; Jancic, Carolina; Bezares, Raimundo F; Bitsmans, Alicia; González, Miguel; Rodríguez, Andrea L; Galmarini, Carlos M; Gamberale, Romina; Giordano, Mirta.

Affiliation

Morande PE; Laboratory of Immunology, IIHEMA, National Academy of Medicine, Buenos Aires, Argentina.

Invest New Drugs ; 30(5): 1830-40, 2012 Oct.

Article in En | MEDLINE | ID: mdl-21887502

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Depsipeptides/pharmacology; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Leukocytes, Mononuclear/drug effects; Monocytes/drug effects; Monocytes/pathology; Aged; Aged, 80 and over; Apoptosis/drug effects; Caspase 3/metabolism; Cell Death/drug effects; Cell Survival/drug effects; Cyclophosphamide/administration & dosage; Depsipeptides/administration & dosage; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/blood; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Leukocytes, Mononuclear/metabolism; Leukocytes, Mononuclear/pathology; Male; Middle Aged; Monocytes/metabolism; Peptides, Cyclic; Poly(ADP-ribose) Polymerases/metabolism; Reactive Oxygen Species/metabolism; Vidarabine/administration & dosage; Vidarabine/analogs & derivatives

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / Monocytes / Leukemia, Lymphocytic, Chronic, B-Cell / Antineoplastic Combined Chemotherapy Protocols / Depsipeptides Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2012 Type: Article Affiliation country: Argentina

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