The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation.

Papakosta, Marianthi; Dalle, Carine; Haythornthwaite, Alison; Cao, Lishuang; Stevens, Edward B; Burgess, Gillian; Russell, Rachel; Cox, Peter J; Phillips, Stephen C; Grimm, Christian

Papakosta, Marianthi; Dalle, Carine; Haythornthwaite, Alison; Cao, Lishuang; Stevens, Edward B; Burgess, Gillian; Russell, Rachel; Cox, Peter J; Phillips, Stephen C; Grimm, Christian.

Affiliation

Papakosta M; Pain Research Unit, Pfizer Global Research and Development, CT139NJ Sandwich, United Kingdom. thouli23@yahoo.co.uk

J Biol Chem ; 286(45): 39663-72, 2011 Nov 11.

Article in En | MEDLINE | ID: mdl-21911503

Subject(s)

Hot Temperature; TRPV Cation Channels/metabolism; Animals; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins/antagonists & inhibitors; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Species Specificity; Sulfonamides/pharmacology; TRPV Cation Channels/antagonists & inhibitors; TRPV Cation Channels/genetics; Thiourea/analogs & derivatives; Thiourea/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: TRPV Cation Channels / Hot Temperature Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United kingdom

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