The efficacy and safety of imipenem/cilastatin in the treatment of severe bacterial infections.

D'Amato, C; Armignacco, O; Antonucci, G; Bordi, E; Bove, G; De Carli, G; De Mori, P; Rosci, M A; Visco, G

D'Amato, C; Armignacco, O; Antonucci, G; Bordi, E; Bove, G; De Carli, G; De Mori, P; Rosci, M A; Visco, G.

Affiliation

D'Amato C; L. Spallanzani Hospital, Rome, Italy.

J Chemother ; 2(2): 100-7, 1990 Apr.

Article in En | MEDLINE | ID: mdl-2193998

ABSTRACT

ABSTRACT

We have assessed the efficacy and safety of imipenem/cilastatin in a non-comparative study of 27 immunocompromised patients suffering from severe bacterial infections. Moreover in two groups of 14 patients the efficacy of imipenem/cilastatin versus a standard broad spectrum antibiotic therapy has also been compared. Clinical and microbiological efficacy and side effects have been evaluated.

Subject(s)

Bacterial Infections/drug therapy; Cilastatin/therapeutic use; Imipenem/therapeutic use; Adolescent; Adult; Aged; Cilastatin/adverse effects; Drug Synergism; Drug Therapy, Combination; Endocarditis, Bacterial/drug therapy; Female; Humans; Imipenem/adverse effects; Male; Middle Aged; Prospective Studies; Randomized Controlled Trials as Topic; Urinary Tract Infections/drug therapy; Urinary Tract Infections/microbiology

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Cilastatin / Imipenem Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Chemother Journal subject: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Year: 1990 Type: Article Affiliation country: Italy

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