Disruption of Na+,HCO3â» cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²âº sensitivity, and hypertension development in mice.

Boedtkjer, Ebbe; Praetorius, Jeppe; Matchkov, Vladimir V; Stankevicius, Edgaras; Mogensen, Susie; Füchtbauer, Annette C; Simonsen, Ulf; Füchtbauer, Ernst-Martin; Aalkjaer, Christian

Disruption of Na+,HCO3â» cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²âº sensitivity, and hypertension development in mice.

Boedtkjer, Ebbe; Praetorius, Jeppe; Matchkov, Vladimir V; Stankevicius, Edgaras; Mogensen, Susie; Füchtbauer, Annette C; Simonsen, Ulf; Füchtbauer, Ernst-Martin; Aalkjaer, Christian.

Affiliation

Boedtkjer E; Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark. eb@fi.au.dk

Circulation ; 124(17): 1819-29, 2011 Oct 25.

Article in En | MEDLINE | ID: mdl-21947296

Subject(s)

Calcium/physiology; Hypertension/prevention & control; Muscle, Smooth, Vascular/physiopathology; Nitric Oxide/antagonists & inhibitors; Nitric Oxide/physiology; Sodium-Bicarbonate Symporters/deficiency; Sodium-Hydrogen Exchangers/antagonists & inhibitors; Vasodilation/physiology; Animals; Calcium Signaling/genetics; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Endothelium, Vascular/physiology; Hypertension/genetics; Hypertension/metabolism; Mesenteric Arteries/drug effects; Mesenteric Arteries/metabolism; Mesenteric Arteries/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/drug effects; Organ Culture Techniques; Sodium-Bicarbonate Symporters/biosynthesis; Sodium-Bicarbonate Symporters/genetics; Sodium-Hydrogen Exchangers/biosynthesis; Sodium-Hydrogen Exchangers/genetics; Vasodilation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Calcium / Sodium-Hydrogen Exchangers / Sodium-Bicarbonate Symporters / Hypertension / Muscle, Smooth, Vascular / Nitric Oxide Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Circulation Year: 2011 Type: Article Affiliation country: Denmark

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