Calcineurin inhibitors acutely improve insulin sensitivity without affecting insulin secretion in healthy human volunteers.

Øzbay, Lara Aygen; Møller, Niels; Juhl, Claus; Bjerre, Mette; Carstens, Jan; Rungby, Jørgen; Jørgensen, Kaj Anker

Øzbay, Lara Aygen; Møller, Niels; Juhl, Claus; Bjerre, Mette; Carstens, Jan; Rungby, Jørgen; Jørgensen, Kaj Anker.

Affiliation

Øzbay LA; Department of Nephrology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, Aarhus, Denmark. doc.aygen@gmail.com

Br J Clin Pharmacol ; 73(4): 536-45, 2012 Apr.

Article in En | MEDLINE | ID: mdl-21988494

Subject(s)

Calcineurin Inhibitors; Cyclosporine/administration & dosage; Immunosuppressive Agents/administration & dosage; Insulin Resistance/physiology; Insulin/metabolism; Tacrolimus/administration & dosage; Adult; Analysis of Variance; Calcineurin/blood; Cross-Over Studies; Diabetes Mellitus/prevention & control; Double-Blind Method; Glucose/metabolism; Glucose Clamp Technique/methods; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin Secretion; Male; Middle Aged; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Tacrolimus / Cyclosporine / Calcineurin Inhibitors / Immunosuppressive Agents / Insulin Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2012 Type: Article Affiliation country: Denmark

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