The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels.

Merchant, Akil A; Singh, Anju; Matsui, William; Biswal, Shyam

Merchant, Akil A; Singh, Anju; Matsui, William; Biswal, Shyam.

Affiliation

Merchant AA; Division of Hematology, Department of Medicine, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Blood ; 118(25): 6572-9, 2011 Dec 15.

Article in En | MEDLINE | ID: mdl-22039262

Subject(s)

Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; NF-E2-Related Factor 2/physiology; Reactive Oxygen Species/metabolism; Acetylcysteine/pharmacology; Animals; Apoptosis/drug effects; Bone Marrow Cells/cytology; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Bone Marrow Transplantation; Cell Proliferation/drug effects; Cell Survival/drug effects; Cytokines/genetics; Flow Cytometry; Free Radical Scavengers/pharmacology; Gene Expression Profiling; Granulocyte Colony-Stimulating Factor/pharmacology; Hematopoietic Stem Cells/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2/deficiency; NF-E2-Related Factor 2/genetics; Oxidation-Reduction; Oxidative Stress/drug effects; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Reactive Oxygen Species / NF-E2-Related Factor 2 Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

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