Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme.

Dammanahalli, Jagadeesha K; Duffel, Michael W

Dammanahalli, Jagadeesha K; Duffel, Michael W.

Affiliation

Dammanahalli JK; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S. Grand Ave., Iowa City, IA 52242, USA.

Drug Metab Dispos ; 40(2): 298-303, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22041107

Subject(s)

Arylsulfotransferase/metabolism; Dimethylformamide/analogs & derivatives; Liver/enzymology; Oxidants/pharmacology; tert-Butylhydroperoxide/pharmacology; Animals; Arylsulfotransferase/chemistry; Arylsulfotransferase/genetics; Cell Survival/drug effects; Dimethylformamide/pharmacology; Glutathione/metabolism; In Vitro Techniques; Kinetics; Liver/drug effects; Liver/metabolism; Male; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recombinant Proteins/agonists; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Umbelliferones/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arylsulfotransferase / Oxidants / Tert-Butylhydroperoxide / Dimethylformamide / Liver Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2012 Type: Article Affiliation country: United States

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