An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain.

Weber, J Mark; Cernota, William H; Gonzalez, Melissa C; Leach, Benjamin I; Reeves, Andrew R; Wesley, Roy K

Weber, J Mark; Cernota, William H; Gonzalez, Melissa C; Leach, Benjamin I; Reeves, Andrew R; Wesley, Roy K.

Affiliation

Weber JM; Fermalogic, Inc, 920 North Franklin Street, Chicago, IL 60610, USA. mark.weber@fermalogic.com

Appl Microbiol Biotechnol ; 93(4): 1575-83, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22048617

Subject(s)

Anti-Bacterial Agents/biosynthesis; Erythromycin/biosynthesis; Malonates/metabolism; Saccharopolyspora/metabolism; Culture Media/chemistry; Drug Tolerance; Fermentation; Gene Deletion; Malonates/toxicity; Metabolic Engineering; Methylmalonyl-CoA Mutase/deficiency; Phenotype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Erythromycin / Saccharopolyspora / Malonates / Anti-Bacterial Agents Language: En Journal: Appl Microbiol Biotechnol Year: 2012 Type: Article Affiliation country: United States

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