Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice.

Bundgaard, Christoffer; Jensen, Christian Jes Nyberg; Garmer, Mats

Bundgaard, Christoffer; Jensen, Christian Jes Nyberg; Garmer, Mats.

Affiliation

Bundgaard C; Discovery DMPK, H. Lundbeck A/S, Valby, Denmark. cbun@lundbeck.com

Drug Metab Dispos ; 40(3): 461-6, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22112383

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP Binding Cassette Transporter, Subfamily B/deficiency; Brain/metabolism; ATP Binding Cassette Transporter, Subfamily B/genetics; ATP Binding Cassette Transporter, Subfamily B/metabolism; Animals; Aripiprazole; Biological Transport; Blood-Brain Barrier/metabolism; Citalopram/administration & dosage; Citalopram/pharmacokinetics; Cyclohexanols/administration & dosage; Cyclohexanols/pharmacokinetics; Gene Knockout Techniques/methods; Genotype; Mice; Piperazines/administration & dosage; Piperazines/pharmacokinetics; Quinolones/administration & dosage; Quinolones/pharmacokinetics; Rats; Risperidone/administration & dosage; Risperidone/pharmacokinetics; Species Specificity; Venlafaxine Hydrochloride

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP Binding Cassette Transporter, Subfamily B Type of study: Qualitative_research Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2012 Type: Article Affiliation country: Denmark

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