miR-29b participates in early aneurysm development in Marfan syndrome.

Merk, Denis R; Chin, Jocelyn T; Dake, Benjamin A; Maegdefessel, Lars; Miller, Miquell O; Kimura, Naoyuki; Tsao, Philip S; Iosef, Cristiana; Berry, Gerald J; Mohr, Friedrich W; Spin, Joshua M; Alvira, Cristina M; Robbins, Robert C; Fischbein, Michael P

Merk, Denis R; Chin, Jocelyn T; Dake, Benjamin A; Maegdefessel, Lars; Miller, Miquell O; Kimura, Naoyuki; Tsao, Philip S; Iosef, Cristiana; Berry, Gerald J; Mohr, Friedrich W; Spin, Joshua M; Alvira, Cristina M; Robbins, Robert C; Fischbein, Michael P.

Affiliation

Merk DR; Department of Cardiothoracic Surgery, 300 Pasteur Drive, Falk Cardiovascular Research Building, Stanford University, Stanford, CA 94305, USA.

Circ Res ; 110(2): 312-24, 2012 Jan 20.

Article in En | MEDLINE | ID: mdl-22116819

Subject(s)

Aorta/metabolism; Aortic Aneurysm/metabolism; Marfan Syndrome/metabolism; MicroRNAs/metabolism; Age Factors; Angiotensin II Type 1 Receptor Blockers/pharmacology; Animals; Aorta/pathology; Aortic Aneurysm/genetics; Aortic Aneurysm/pathology; Aortic Aneurysm/prevention & control; Apoptosis; Apoptosis Regulatory Proteins/metabolism; Cells, Cultured; Disease Models, Animal; Elastin/genetics; Elastin/metabolism; Female; Fibrillin-1; Fibrillins; Genetic Therapy/methods; Losartan/pharmacology; Male; Marfan Syndrome/complications; Marfan Syndrome/genetics; Marfan Syndrome/pathology; Marfan Syndrome/therapy; Matrix Metalloproteinase 2/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs/genetics; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; NF-kappa B/metabolism; Oligonucleotides, Antisense/administration & dosage; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta/metabolism; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Aortic Aneurysm / MicroRNAs / Marfan Syndrome Type of study: Prognostic_studies Language: En Journal: Circ Res Year: 2012 Type: Article Affiliation country: United States

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