Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.

Levaot, Noam; Voytyuk, Oleksandr; Dimitriou, Ioannis; Sircoulomb, Fabrice; Chandrakumar, Arun; Deckert, Marcel; Krzyzanowski, Paul M; Scotter, Andrew; Gu, Shengqing; Janmohamed, Salima; Cong, Feng; Simoncic, Paul D; Ueki, Yasuyoshi; La Rose, Jose; Rottapel, Robert

Levaot, Noam; Voytyuk, Oleksandr; Dimitriou, Ioannis; Sircoulomb, Fabrice; Chandrakumar, Arun; Deckert, Marcel; Krzyzanowski, Paul M; Scotter, Andrew; Gu, Shengqing; Janmohamed, Salima; Cong, Feng; Simoncic, Paul D; Ueki, Yasuyoshi; La Rose, Jose; Rottapel, Robert.

Affiliation

Levaot N; Ontario Cancer Institute and the Campbell Family Cancer Research Institute, 101 College Street, Rm 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

Cell ; 147(6): 1324-39, 2011 Dec 09.

Article in En | MEDLINE | ID: mdl-22153076

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cherubism/metabolism; Signal Transduction; Tankyrases/metabolism; Adaptor Proteins, Signal Transducing/genetics; Animals; Cherubism/genetics; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Macrophages/metabolism; Osteoclasts/metabolism; Protein Stability; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-vav/metabolism; Sequence Deletion; Syk Kinase; Tankyrases/genetics; Tumor Necrosis Factor-alpha/metabolism; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cherubism / Tankyrases / Adaptor Proteins, Signal Transducing Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2011 Type: Article Affiliation country: Canada

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