Nanoerythropoietin is 10-times more effective than regular erythropoietin in neuroprotection in a neonatal rat model of hypoxia and ischemia.

Chen, Han; Spagnoli, Frédéric; Burris, Michael; Rolland, William B; Fajilan, Adriel; Dou, Huanyu; Tang, Jiping; Zhang, John H

Chen, Han; Spagnoli, Frédéric; Burris, Michael; Rolland, William B; Fajilan, Adriel; Dou, Huanyu; Tang, Jiping; Zhang, John H.

Affiliation

Chen H; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92324, USA.

Stroke ; 43(3): 884-7, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22156696

Subject(s)

Brain Ischemia/drug therapy; Erythropoietin/pharmacology; Hypoxia, Brain/drug therapy; Neuroprotective Agents; Animals; Animals, Newborn; Behavior, Animal/drug effects; Brain Ischemia/pathology; Brain Ischemia/psychology; Cerebral Infarction/drug therapy; Cerebral Infarction/pathology; Cerebral Infarction/psychology; Erythropoietin/administration & dosage; Excipients; Female; Hypoxia, Brain/pathology; Hypoxia, Brain/psychology; Injections, Intraperitoneal; Lactic Acid; Male; Nanoparticles; Nervous System Diseases/prevention & control; Nervous System Diseases/psychology; Organ Size/physiology; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Postural Balance/physiology; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rotarod Performance Test

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hypoxia, Brain / Brain Ischemia / Erythropoietin / Neuroprotective Agents Limits: Animals Language: En Journal: Stroke Year: 2012 Type: Article Affiliation country: United States

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