[Clinical evaluation of atracurium besylate in patients at risk: major burns]. / Valutazione clinica dell'atracurium besilato nei pazienti a rischio: il grande ustionato.
Minerva Anestesiol
; 56(4): 121-5, 1990 Apr.
Article
in It
| MEDLINE
| ID: mdl-2215995
ABSTRACT
Atracurium besylate 0.5 mg/kg-1, an intermediate-duration non-depolarizing neuromuscular relaxant, was administered slowly (over 75 sec) in anesthesia induction of 61 patients with major thermal injury undergoing surgical excision and immediate skin-grafting procedures. Patients' mean +/- SD age was 40 +/- 9, body weight 64 +/- 2, burn size ranging from 20% to 90% of body surface area (BSA), postburn day of surgery 5th and more. Induction of anesthesia was carried out with sodium thiopental 2-5 mg/kg-1 plus fentanyl 2.8 micrograms/kg-1 e.v. and after few minutes atracurium 0.5 mg/kg-1 e.v. Anesthesia was maintained with N2O/O2 (70%/30%), isoflurane and small amounts of fentanyl. The mean arterial pressure and heart rate were recorded at I, II, III, IV, V min post atracurium administration. The endotracheal intubation conditions were assessed by a "IOT score". Results are expressed as mean value +/- standard deviation. The significance of the difference in mean values was analysed by t-test. Little haemodynamic changes occurred; intubating conditions showed a relative hyposensitivity of burn patients to atracurium, more severely burned patients (greater than 50-60%) exhibiting greater resistance.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Atracurium
/
Burns
/
Anesthesia
Type of study:
Etiology_studies
/
Health_economic_evaluation
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Minerva Anestesiol
Year:
1990
Type:
Article