The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.

Crowe, Andrew; Wright, Cameron

Crowe, Andrew; Wright, Cameron.

Affiliation

Crowe A; School of Pharmacy and Curtin Health Innovative Research Institute (CHIRI), Curtin University, Perth, Western Australia. a.p.crowe@curtin.edu.au

Xenobiotica ; 42(6): 538-49, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22188412

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology; Histamine H1 Antagonists/pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Biological Transport; Caco-2 Cells; Cetirizine/pharmacokinetics; Chromatography, High Pressure Liquid; Drug Interactions; Histamine H1 Antagonists/metabolism; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Loratadine/analogs & derivatives; Loratadine/pharmacokinetics; Mass Spectrometry; Permeability; Terfenadine/analogs & derivatives; Terfenadine/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP Binding Cassette Transporter, Subfamily B, Member 1 / Histamine H1 Antagonists Limits: Humans Language: En Journal: Xenobiotica Year: 2012 Type: Article

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