Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.

Antoniades, Charalambos; Demosthenous, Michael; Reilly, Svetlana; Margaritis, Marios; Zhang, Mei-Hua; Antonopoulos, Alexios; Marinou, Kyriakoula; Nahar, Keshav; Jayaram, Raja; Tousoulis, Dimitris; Bakogiannis, Constantinos; Sayeed, Rana; Triantafyllou, Costas; Koumallos, Nikolaos; Psarros, Costas; Miliou, Antigoni; Stefanadis, Christodoulos; Channon, Keith M; Casadei, Barbara

Antoniades, Charalambos; Demosthenous, Michael; Reilly, Svetlana; Margaritis, Marios; Zhang, Mei-Hua; Antonopoulos, Alexios; Marinou, Kyriakoula; Nahar, Keshav; Jayaram, Raja; Tousoulis, Dimitris; Bakogiannis, Constantinos; Sayeed, Rana; Triantafyllou, Costas; Koumallos, Nikolaos; Psarros, Costas; Miliou, Antigoni; Stefanadis, Christodoulos; Channon, Keith M; Casadei, Barbara.

Affiliation

Antoniades C; Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. antoniad@well.ox.ac.uk

J Am Coll Cardiol ; 59(1): 60-70, 2012 Jan 03.

Article in En | MEDLINE | ID: mdl-22192670

Subject(s)

Cardiac Surgical Procedures/methods; Heptanoic Acids/administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage; Oxidation-Reduction/drug effects; Pyrroles/administration & dosage; Aged; Atorvastatin; Cardiac Surgical Procedures/adverse effects; Cardiac Surgical Procedures/mortality; Confidence Intervals; Coronary Artery Bypass/adverse effects; Coronary Artery Bypass/methods; Coronary Artery Bypass/mortality; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hospital Mortality/trends; Humans; Kaplan-Meier Estimate; Lipid Peroxidation/drug effects; Male; Middle Aged; Myocardium/metabolism; Postoperative Complications/prevention & control; Predictive Value of Tests; Preoperative Care/methods; Proportional Hazards Models; Prospective Studies; Survival Analysis; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidation-Reduction / Pyrroles / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Cardiac Surgical Procedures / Heptanoic Acids Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Am Coll Cardiol Year: 2012 Type: Article Affiliation country: United kingdom

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