Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.

Labbé, Katherine; McIntire, Christian R; Doiron, Karine; Leblanc, Philippe M; Saleh, Maya

Labbé, Katherine; McIntire, Christian R; Doiron, Karine; Leblanc, Philippe M; Saleh, Maya.

Affiliation

Labbé K; Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada.

Immunity ; 35(6): 897-907, 2011 Dec 23.

Article in En | MEDLINE | ID: mdl-22195745

Subject(s)

Caspase 1/metabolism; Inflammasomes/metabolism; Inhibitor of Apoptosis Proteins/metabolism; Animals; Enzyme Activation/genetics; HEK293 Cells; Humans; Inflammation/genetics; Inflammation/metabolism; Inhibitor of Apoptosis Proteins/deficiency; Inhibitor of Apoptosis Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspase 1 / Inhibitor of Apoptosis Proteins / Inflammasomes Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2011 Type: Article Affiliation country: Canada

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