Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.

Zhou, Rui-Hai; Vendrov, Aleksandr E; Tchivilev, Igor; Niu, Xi-Lin; Molnar, Kimberly C; Rojas, Mauricio; Carter, Jacqueline D; Tong, Haiyan; Stouffer, George A; Madamanchi, Nageswara R; Runge, Marschall S

Zhou, Rui-Hai; Vendrov, Aleksandr E; Tchivilev, Igor; Niu, Xi-Lin; Molnar, Kimberly C; Rojas, Mauricio; Carter, Jacqueline D; Tong, Haiyan; Stouffer, George A; Madamanchi, Nageswara R; Runge, Marschall S.

Affiliation

Zhou RH; McAllister Heart Institute, Department of Medicine, 125 MacNaider Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7005, USA.

Arterioscler Thromb Vasc Biol ; 32(3): 745-55, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22199367

Subject(s)

Aging/metabolism; Aortic Diseases/metabolism; Mitochondria/metabolism; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Oxidative Stress; Actins/metabolism; Age Factors; Aging/pathology; Animals; Aorta/metabolism; Aorta/physiopathology; Aortic Diseases/diagnostic imaging; Aortic Diseases/genetics; Aortic Diseases/physiopathology; Apoptosis; Cells, Cultured; Collagen Type I/metabolism; Compliance; Disease Models, Animal; Elastin/metabolism; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/metabolism; Genotype; Hydrogen Peroxide/metabolism; Insulin-Like Growth Factor I/metabolism; Matrix Metalloproteinase 2/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria/pathology; Mitogen-Activated Protein Kinase 8/metabolism; Muscle, Smooth, Vascular/diagnostic imaging; Muscle, Smooth, Vascular/physiopathology; Myocytes, Smooth Muscle/pathology; NADPH Oxidases/deficiency; NADPH Oxidases/genetics; Phenotype; Proto-Oncogene Proteins c-akt/metabolism; Pulsatile Flow; Stroke Volume; Superoxide Dismutase/deficiency; Superoxide Dismutase/genetics; Superoxide Dismutase-1; Superoxides/metabolism; Transfection; Ultrasonography, Doppler, Pulsed; Vasodilation; Ventricular Function, Left; Ventricular Pressure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Diseases / Aging / Oxidative Stress / Myocytes, Smooth Muscle / Mitochondria / Muscle, Smooth, Vascular Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2012 Type: Article Affiliation country: United States

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