The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria.

Zhao, Yi; Spigolon, Giada; Bonny, Christophe; Culman, Juraj; Vercelli, Alessandro; Herdegen, Thomas

Zhao, Yi; Spigolon, Giada; Bonny, Christophe; Culman, Juraj; Vercelli, Alessandro; Herdegen, Thomas.

Affiliation

Zhao Y; Institute for Experimental and Clinical Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospital Strasse 4, 24105 Kiel, Germany.

Mol Cell Neurosci ; 49(3): 300-10, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22206897

Subject(s)

Brain/metabolism; Cytochromes c/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Mitochondria/metabolism; Peptides/pharmacology; Poly(ADP-ribose) Polymerases/metabolism; Animals; Apoptosis/physiology; Cytochromes c/drug effects; Disease Models, Animal; Hippocampus/metabolism; JNK Mitogen-Activated Protein Kinases/physiology; MAP Kinase Signaling System/physiology; Male; Mitochondria/drug effects; Mitogen-Activated Protein Kinase Kinases/metabolism; Phosphorylation/drug effects; Rats; Rats, Sprague-Dawley; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Brain / Poly(ADP-ribose) Polymerases / Cytochromes c / JNK Mitogen-Activated Protein Kinases / Mitochondria Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Cell Neurosci Journal subject: BIOLOGIA MOLECULAR / NEUROLOGIA Year: 2012 Type: Article Affiliation country: Germany

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