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Hemopoiesis-stimulating activity of immobilized oligonucleotides and hyaluronidase during cytostatic-induced myelosuppression.
Dygai, A M; Skurikhin, E G; Pershina, O V; Zhdanov, V V; Khmelevskaya, A M; Andreeva, T V; Poponina, A M; Zjuzkov, G N; Udut, E V; Khrichkova, T Ju; Simanina, E V; Miroshnichenko, L A; Stavrova, L A; Tchaikovsky, A S; Markova, T S; Gurto, R V; Brjushinina, O S; Slepichev, V A.
Affiliation
  • Dygai AM; Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
Bull Exp Biol Med ; 150(5): 614-8, 2011 Mar.
Article in En | MEDLINE | ID: mdl-22235398
ABSTRACT
The hemopoiesis-stimulating effect of combined treatment with immobilized oligonucleotides and hyaluronidase preparations was studied during cytostatic-induced myelosuppression caused by cyclophosphamide administration. Immobilized hyaluronidase was shown to increase the efficiency of correction of changes in the erythroid and granulocytic hemopoietic stems with immobilized oligonucleotides. This potentiation of the effect of immobilized oligonucleotides by immobilized hyaluronidase was related to an increase in functional activity of committed hemopoietic precursors.
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Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Hematopoietic Stem Cells / Cell Differentiation / Hematopoiesis / Hyaluronoglucosaminidase Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2011 Type: Article Affiliation country: RUSSIA
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Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Hematopoietic Stem Cells / Cell Differentiation / Hematopoiesis / Hyaluronoglucosaminidase Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2011 Type: Article Affiliation country: RUSSIA