Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.

Younis, Husam S; Crosby, Jeff; Huh, Jung-Im; Lee, Hong Soo; Rime, Soyub; Monia, Brett; Henry, Scott P

Younis, Husam S; Crosby, Jeff; Huh, Jung-Im; Lee, Hong Soo; Rime, Soyub; Monia, Brett; Henry, Scott P.

Affiliation

Younis HS; Preclinical Development, ISIS Pharmaceuticals, Carlsbad, CA, USA. hyounis@isisph.com

Blood ; 119(10): 2401-8, 2012 Mar 08.

Article in En | MEDLINE | ID: mdl-22246038

Subject(s)

Factor XI/antagonists & inhibitors; Hemorrhage/prevention & control; Oligonucleotides, Antisense/pharmacology; Partial Thromboplastin Time; Animals; Blood Coagulation/drug effects; Dose-Response Relationship, Drug; Drug Administration Schedule; Factor XI/genetics; Factor XI/metabolism; Female; Gene Expression Regulation/drug effects; Hemorrhage/blood; Infusions, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Male; Oligonucleotides/administration & dosage; Oligonucleotides/genetics; Oligonucleotides, Antisense/administration & dosage; Oligonucleotides, Antisense/genetics; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Treatment Outcome

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Partial Thromboplastin Time / Factor XI / Oligonucleotides, Antisense / Hemorrhage Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google