Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.

Stockwell, Simon R; Platt, Georgina; Barrie, S Elaine; Zoumpoulidou, Georgia; Te Poele, Robert H; Aherne, G Wynne; Wilson, Stuart C; Sheldrake, Peter; McDonald, Edward; Venet, Mathilde; Soudy, Christelle; Elustondo, Frédéric; Rigoreau, Laurent; Blagg, Julian; Workman, Paul; Garrett, Michelle D; Mittnacht, Sibylle

Stockwell, Simon R; Platt, Georgina; Barrie, S Elaine; Zoumpoulidou, Georgia; Te Poele, Robert H; Aherne, G Wynne; Wilson, Stuart C; Sheldrake, Peter; McDonald, Edward; Venet, Mathilde; Soudy, Christelle; Elustondo, Frédéric; Rigoreau, Laurent; Blagg, Julian; Workman, Paul; Garrett, Michelle D; Mittnacht, Sibylle.

Affiliation

Stockwell SR; Research Department of Cancer Biology, UCL Cancer Institute, London, United Kingdom.

PLoS One ; 7(1): e28568, 2012.

Article in En | MEDLINE | ID: mdl-22253692

Subject(s)

Enzyme Activators/pharmacology; G1 Phase Cell Cycle Checkpoints/drug effects; S Phase Cell Cycle Checkpoints/drug effects; Signal Transduction/drug effects; eIF-2 Kinase/metabolism; Animals; Cluster Analysis; Cyclin D1/metabolism; DNA, Complementary/genetics; Drug Evaluation, Preclinical; Drug Interactions; Endoplasmic Reticulum Stress/drug effects; Enzyme Activation/drug effects; Enzyme Activators/chemistry; Eukaryotic Initiation Factor-2/metabolism; Humans; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Paclitaxel/pharmacology; Phosphorylation/drug effects; Retinoblastoma Protein/metabolism; Transcriptome/drug effects; Transcriptome/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / EIF-2 Kinase / Enzyme Activators / G1 Phase Cell Cycle Checkpoints / S Phase Cell Cycle Checkpoints Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google