The IL-7R&#945; pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

Kreft, Karim L; Verbraak, Evert; Wierenga-Wolf, Annet F; van Meurs, Marjan; Oostra, Ben A; Laman, Jon D; Hintzen, Rogier Q

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

Kreft, Karim L; Verbraak, Evert; Wierenga-Wolf, Annet F; van Meurs, Marjan; Oostra, Ben A; Laman, Jon D; Hintzen, Rogier Q.

Affiliation

Kreft KL; Department of Neurology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands.

J Immunol ; 188(4): 1874-83, 2012 Feb 15.

Article in En | MEDLINE | ID: mdl-22262655

Subject(s)

CD8-Positive T-Lymphocytes/immunology; Multiple Sclerosis/immunology; Receptors, Interleukin-7/genetics; Receptors, Interleukin-7/metabolism; Adolescent; Adult; Aged; CD4-Positive T-Lymphocytes/immunology; Female; Granzymes/biosynthesis; Humans; Interleukin-7/immunology; Male; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Middle Aged; Multiple Sclerosis/genetics; Polymorphism, Single Nucleotide; RNA, Messenger/biosynthesis; STAT5 Transcription Factor/biosynthesis; STAT5 Transcription Factor/metabolism; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Receptors, Interleukin-7 / Multiple Sclerosis Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2012 Type: Article Affiliation country: Netherlands

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