Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.

Kawabata, Takumi; Tanimura, Susumu; Asai, Kohei; Kawasaki, Ryohei; Matsumaru, Yumi; Kohno, Michiaki

Kawabata, Takumi; Tanimura, Susumu; Asai, Kohei; Kawasaki, Ryohei; Matsumaru, Yumi; Kohno, Michiaki.

Affiliation

Kawabata T; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521.
Tanimura S; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521,; Nagasaki University Research Center for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki 852-8523, and.
Asai K; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521.
Kawasaki R; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521.
Matsumaru Y; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521.
Kohno M; Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521,; Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto 606-8501, Japan. Electronic address: kohnom@na

J Biol Chem ; 287(13): 10289-10300, 2012 Mar 23.

Article in En | MEDLINE | ID: mdl-22270368

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Apoptosis/drug effects; Enzyme Inhibitors/pharmacology; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Gene Expression Regulation, Neoplastic/drug effects; MAP Kinase Signaling System/drug effects; Membrane Proteins/metabolism; Neoplasms/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins/metabolism; Apoptosis/genetics; Apoptosis Regulatory Proteins/genetics; Bcl-2-Like Protein 11; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Cell Cycle Checkpoints/drug effects; Cell Cycle Checkpoints/genetics; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Down-Regulation/drug effects; Down-Regulation/genetics; Extracellular Signal-Regulated MAP Kinases/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Expression Regulation, Neoplastic/genetics; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System/genetics; Mad2 Proteins; Membrane Proteins/genetics; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms/genetics; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; Repressor Proteins/genetics; Repressor Proteins/metabolism; Up-Regulation/drug effects; Up-Regulation/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / MAP Kinase Signaling System / Extracellular Signal-Regulated MAP Kinases / Enzyme Inhibitors / Apoptosis Regulatory Proteins / Membrane Proteins / Neoplasms Language: En Journal: J Biol Chem Year: 2012 Type: Article

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