The different flexibility of c-Src and c-Abl kinases regulates the accessibility of a druggable inactive conformation.

Lovera, Silvia; Sutto, Ludovico; Boubeva, Ralitza; Scapozza, Leonardo; Dölker, Nicole; Gervasio, Francesco L

Lovera, Silvia; Sutto, Ludovico; Boubeva, Ralitza; Scapozza, Leonardo; Dölker, Nicole; Gervasio, Francesco L.

Affiliation

Lovera S; Structural Biology and Biocomputing Programme, Spanish National Cancer Research Center (CNIO), Melchor Fernandez Almagro 3, E-28029 Madrid, Spain.

J Am Chem Soc ; 134(5): 2496-9, 2012 Feb 08.

Article in En | MEDLINE | ID: mdl-22280319

Subject(s)

Oligopeptides/chemistry; Proto-Oncogene Proteins c-abl/metabolism; src-Family Kinases/metabolism; Calorimetry; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Proto-Oncogene Proteins c-abl/chemistry; src-Family Kinases/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Proto-Oncogene Proteins c-abl / Src-Family Kinases Language: En Journal: J Am Chem Soc Year: 2012 Type: Article Affiliation country: Spain

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