Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.

Jeon, Bu-Nam; Kim, Yeon-Sook; Choi, Won-Il; Koh, Dong-In; Kim, Min-Kyeong; Yoon, Jae-Hyeon; Kim, Min-Young; Hur, Benjamin; Paik, Philip Dong-Hyun; Hur, Man-Wook

Jeon, Bu-Nam; Kim, Yeon-Sook; Choi, Won-Il; Koh, Dong-In; Kim, Min-Kyeong; Yoon, Jae-Hyeon; Kim, Min-Young; Hur, Benjamin; Paik, Philip Dong-Hyun; Hur, Man-Wook.

Affiliation

Jeon BN; Department of Biochemistry, Brain Korea 21 Project for Medical Science, Severance Biomedical Research Institute, Yonsei University School of Medicine, 134, ShinChon-Dong, SeoDaeMoon-Ku, Seoul, 120-752, Korea.

J Lipid Res ; 53(4): 755-66, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22331133

Subject(s)

Fatty Acid Synthase, Type I/metabolism; Promoter Regions, Genetic; Proteins/metabolism; Sterol Regulatory Element Binding Protein 1/metabolism; 3T3-L1 Cells; Animals; Cell Dedifferentiation; Cell Differentiation; Cell Proliferation; Doxycycline/pharmacology; Electrophoretic Mobility Shift Assay; Enzyme Activation; Fatty Acid Synthase, Type I/genetics; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; HEK293 Cells; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Mice; Pregnancy; Protein Binding; Protein Interaction Domains and Motifs; Proteins/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sterol Regulatory Element Binding Protein 1/genetics; Transcriptional Activation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Promoter Regions, Genetic / Sterol Regulatory Element Binding Protein 1 / Fatty Acid Synthase, Type I Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: J Lipid Res Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google